{"id":5960,"date":"2025-06-19T19:12:51","date_gmt":"2025-06-19T22:12:51","guid":{"rendered":"https:\/\/kyojin.com.ar\/?page_id=5960"},"modified":"2025-06-19T19:26:08","modified_gmt":"2025-06-19T22:26:08","slug":"celiaquia-y-microbiota","status":"publish","type":"page","link":"https:\/\/kyojin.com.ar\/en\/celiaquia-y-microbiota\/","title":{"rendered":"Celiac Disease"},"content":{"rendered":"

Celiac disease is an autoimmune intestinal disorder that occurs in genetically predisposed individuals when they consume gluten\u2014a protein found in wheat, oats, barley, and rye. The current treatment involves completely eliminating gluten from the diet. Research has shown that the gut microbiota\u2014the community of microorganisms, mainly bacteria, that inhabit our intestines\u2014and particularly probiotics, may play an important role in the prevention and management of the disease.\n\nWhile lactic acid probiotics are beneficial, they are sensitive to digestive conditions and may not reach the intestine in an active form. In contrast, spore-forming probiotics from the Bacillus genus, such as Bacillus subtilis DG101 (Kyojin), are more stable and resilient. Incorporating spore-forming probiotics could be a promising strategy to improve the quality of life for people with celiac disease, beyond a strict gluten-free diet.\n\nThis potential benefit comes from two main factors: first, Bacillus subtilis DG101 helps restore eubiosis (balance) in the gut microbiota, improving digestion and food tolerance; and second, Bacillus subtilis DG101 produces nattokinase, a protease that has been shown (at least in vitro) to degrade gliadin\u2014the main gluten protein responsible for triggering symptoms and discomfort in celiac disease.<\/p>\n\n\n\n

Related Papers:<\/strong><\/p>\n\n\n\n

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  1. Chibbar R and Dieleman L (2019). The gut microbiota in celiac disease and probiotics. Nutrients: 11, 2375, doi:10.3390\/nu11102375.<\/li>\n\n\n\n
  2. Marasco G et al. (2020). Probiotics, prebiotics and other dietary supplements for gut microbiota modulation in celiac disease patients. Nutrients: 12, 2674, doi: 10.3390\/nu12092674.<\/li>\n\n\n\n
  3. Pecora F et al. (2020). Gut microbiota in celiac disease: is there any role for probiotics? Front. Immunol: 11, 957, doi:10.3389\/fommu.2020.00957.<\/li>\n\n\n\n
  4. Wei G et al. (2016). Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease. Am J Physiol Gastrointest Liver Physiol: 311, G571-G580, doi:10.1152\/ajpgi.00185.2016.<\/li>\n\n\n\n
  5. Weng Y et al. (2017). Nattokinase: an oral antithrombotic agent for the prevention of cardiovascular disease. Int J Mol Sci: 18, 523, doi:10.3390\/ijms18030523.<\/li>\n\n\n\n
  6. Ji H et al. (2014). Mechanisms of nattokinase in protection of cerebral ischemia. Eur J Pharmacol 745, 144-151.<\/li>\n\n\n\n
  7. Kim JY et al. (2008). Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res 31, 1583-1588.<\/li>\n\n\n\n
  8. Pham P, Han B, and Hoang B. (2020). Nattospes as effective and safe functional supplements in management of stroke. J Med Food, doi: 10.1089\/jmf.2019.0183.<\/li>\n\n\n\n
  9. Nagata C et al. (2017). Dietary soy and natto intake and cardiovascular disease mortality in Japanese adults: The Takayama study. Am J Clin Nutr, 105: 426-431, doi: 10.3945\/ajcn.116.137281.<\/li>\n<\/ol>\n\n\n\n
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    La celiaqu\u00eda es una enfermedad autoinmune intestinal que se manifiesta en personas con predisposici\u00f3n gen\u00e9tica al consumir gluten, prote\u00edna presente […]<\/p>","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-5960","page","type-page","status-publish","hentry"],"yoast_head":"\nCeliaqu\u00eda - 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